نشر احد تدريسي الجامعة الوطنية للعلوم والتكنولوجيا /كلية التقنيات الطبية بحثا عن دور مركب الالسين المستخلص من نبات الثوم في الحد من ارتفاع مستويات السكر في الدم في مرضى مقاومة الانسولين. ومقارنه فعاليته مع عقار المتفورمين

The Role of Allicin in Regulating Insulin and Glycemic Level in White Mice with Induced Insulin Resistance

Ahmed Nassir Faisal 1

,Zain alabideen almoussawi2,3

National university of science and technology, College of health and medical technologies,Medical laboratory techniques department Iraq.1 Medical laboratory techniques department, Mazzaya University College, Iraq 2. Directorate of Thi-Qar Education, Iraq 3.

Abstract

The current study was carried out from January 2020 to April 2020, to examine the effect of allicin extracted from garlic on some functional variables of rats affected by induced insulin resistance, the results of the current study showed , at the tenth week when subjected to a nutritional system rich with glucose, a marked elevation in fasting serum glucose level, glycated hemoglobin (HbA1C) and insulin hormone, in addition to the presence of noticeable changes in lipid profile represented by significant elevation in the level of serum cholesterol and low-density lipoproteins (LDL), with a reduction in the rate of high-density lipoproteins (HDL). Administration of allicin and metformin at the twelfth week after a nutritional system rich with glucose showed significant changes represented by reduction in fasting serum glucose level, glycated hemoglobin (HbA1c), insulin hormone, serum cholesterol level and LDL, and an elevation in HDL level when compared with the control group, while there were not any significant changes between allicin and metformin

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